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Protagonist Therapeutics

Newark, CA

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Protagonist Therapeutics is a clinical-stage biopharmaceutical company with a proprietary peptide NCE platform and two drugs in late-stage FDA review. Their pipeline targets inflammation, hematology, and metabolic disease using novel oral and injectable peptide therapeutics.

Services Offered

  • Clinical-stage peptide drug development
  • Oral peptide NCE research
  • Inflammation and metabolic disease research
  • Hematology drug development

About

Protagonist Therapeutics has built one of the most advanced clinical-stage peptide pipelines in the US, with two drugs — icotrokinra (an oral IL-23 receptor antagonist for inflammatory disease) and rusfertide (a hepcidin mimetic for hematologic conditions) — each with NDAs filed with the FDA. Their proprietary platform enables the design of orally bioavailable peptide therapeutics, historically a major challenge in drug development.

Peptide Specialties

Icotrokinra (IL-23R oral peptide — NDA under FDA review) Rusfertide (hepcidin mimetic — NDA submitted Dec 2025) Oral IL-17 antagonist Obesity dual/triple receptor agonists

Contact

Newark, CA

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